3-(2-Benzyloxyethyl)oxazolidin-2-one → 2-Oxazolidinone, 3-(2-hydroxyethyl)-
Reaktionsgleichung
C([O:8][CH2:9][CH2:10][N:11]1[CH2:15][CH2:14][O:13][C:12]1=[O:16])C1C=CC=CC=1>CO.[OH-].[Pd+2].[OH-]>[OH:8][CH2:9][CH2:10][N:11]1[CH2:15][CH2:14][O:13][C:12]1=[O:16]Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
20% palladium hydroxide (138 mg) was added to a solution of 3-(2-benzyloxyethyl)oxazolidin-2-one (278 mg) in methanol (10 ml), and the mixture was stirred for 2 hours at room temperature under hydrogen atmosphere. The reaction solution was filtered through celite and then the solvent was evaporated. The residue was purified by silica gel column chromatography (chloroform:methanol=90:10) to yield 3-(2-hydroxyethyl)oxazolidin-2-one (144 mg) as a colorless oil.
Aufarbeitung
- filtrationThe reaction solution was filtered through celite
- customthe solvent was evaporated
- customThe residue was purified by silica gel column chromatography (chloroform:methanol=90:10)
Quellen und Nachweise
- ORD-Eintrag
- ord-e18f69abbc194a298e0adda475a01e70
- Quelldatensatz
- uspto-grants-2010_03
- Patentnummer
- US07678810B2
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