2-Chloro-4-nitropyridine → 4-(2-Chloro-pyridin-4-ylmethyl)-phenylamine
Reaktionsgleichung
FC(F)(F)[C:3]1[CH:8]=[C:7]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=2)[CH:6]=[CH:5][N:4]=1.[Cl:19]C1C=C([N+]([O-])=O)C=CN=1>>[Cl:19][C:3]1[CH:8]=[C:7]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=2)[CH:6]=[CH:5][N:4]=1Komponenten
3
Versuchsvorschrift
4-(2-Chloro-pyridin-4-ylmethyl)-phenylamine was prepared by a method analogous to that described for 4-(2-trifluoromethyl-pyridin-4-ylmethyl)-phenylamine (Intermediate 2P), starting from ethyl (4-nitrophenyl) acetate and 2-chloro-4-nitro-pyridine. 1H NMR (CHCl3-d) δ 8.23 (dd, J=5.1, 0.5 Hz, 1H), 7.11 (m, 1H), 7.01 (m, 1H), 6.95 (m, 2H), 6.65 (m, 2H), 3.83 (s, 2H).
Quellen und Nachweise
- ORD-Eintrag
- ord-0ca0f17587564e98a4a2713068ec575e
- Quelldatensatz
- uspto-grants-2010_03