4-Amino-2,2,6,6-tetramethylpiperidine → 4-(5-amino-2-methylphenyl)-8-(2,6-difluorophenyl)-2-[(2,2,6,6-tetramethyl-4-piperidinyl)amino]pyrido[2,3-d]pyrimidin-7(8H)-one

HRID 2245096

Reaktionsgleichung

Reaktionsgleichung von HRID 2245096
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:31])=[C:6]([C:8]2[C:9]3[CH:21]=[CH:20][C:19](=[O:22])[N:18]([C:23]4[C:28]([F:29])=[CH:27][CH:26]=[CH:25][C:24]=4[F:30])[C:10]=3[N:11]=[C:12](S(C)(=O)=O)[N:13]=2)[CH:7]=1.[CH3:32][C:33]1([CH3:42])[CH2:38][CH:37]([NH2:39])[CH2:36][C:35]([CH3:41])([CH3:40])[NH:34]1>>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:31])=[C:6]([C:8]2[C:9]3[CH:21]=[CH:20][C:19](=[O:22])[N:18]([C:23]4[C:28]([F:29])=[CH:27][CH:26]=[CH:25][C:24]=4[F:30])[C:10]=3[N:11]=[C:12]([NH:39][CH:37]3[CH2:38][C:33]([CH3:42])([CH3:32])[NH:34][C:35]([CH3:41])([CH3:40])[CH2:36]3)[N:13]=2)[CH:7]=1

Komponenten

3

Edukt 2

HCID 375244-Amino-2,2,6,6-tetramethylpiperidineHCID 592126804-(5-amino-2-methylphenyl)-8-(2,6-difluorophenyl)-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one

Produkt 1

HCID 445292194-(5-amino-2-methylphenyl)-8-(2,6-difluorophenyl)-2-[(2,2,6,6-tetramethyl-4-piperidinyl)amino]pyrido[2,3-d]pyrimidin-7(8H)-one

Versuchsvorschrift

The title compound was prepared as described in Example 1d from 4-(5-amino-2-methylphenyl)-8-(2,6-difluorophenyl)-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one and 2,2,6,6-tetramethyl-4-piperidinamine: LC-MS m/z 519 (M+H)+, 1.8 min (ret time).

Aufarbeitung

  1. customLC-MS m/z 519 (M+H)+, 1.8 min (ret time)

Quellen und Nachweise

ORD-Eintrag
ord-db7d6c420e7b49d59d44ebb99772f6a0
Quelldatensatz
uspto-grants-2010_03
Patentnummer
US07678801B2

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