Ammonia → 4,5-Dichloro-2-cyano-imidazole

HRID 224527Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 224527
[Cl:1][C:2]1[N:3]=[C:4]([C:8](Cl)(Cl)Cl)[NH:5][C:6]=1[Cl:7].ClC1C(Cl)=NC(=C(Cl)Cl)[N:14]=1.Cl.N>C(O)C>[Cl:1][C:2]1[N:3]=[C:4]([C:8]#[N:14])[NH:5][C:6]=1[Cl:7]

Komponenten

6

Edukt 4

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 124825724,5-Dichloro-2-(dichloromethylidene)-2H-imidazoleHCID 124825734,5-Dichloro-2-(trichloromethyl)-1H-imidazole

Produkt 1

HCID 139615354,5-Dichloro-2-cyano-imidazoleAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

25.4 g (0.1 mol) of 4,5-dichloro-2-trichloromethylimidazole prepared by treating the 4,5-dichloro-2-dichloromethylene-imidazole with dry HCl at -20° to +600° C., were introduced in small portions into 200 ml of ethanol saturated with ammonia, whilst cooling with ice and stirring vigorously. The mixture was stirred for a further 30 minutes at 50° C., the constituents which had not dissolved were then filtered off and the filtrate was evaporated under reduced pressure. The combined residues were dissolved in hot water. On acidifying the solution with dilute hydrochloric acid, the reaction product precipitated out. This was filtered off, washed with water and dried. In this way 14.6 g (90% of theory) of 4,5-dichloro-2-cyano-imidazole were obtained and after recrystallization from toluene this had a melting point of 187°-189° C.

Aufarbeitung

  1. temperaturewhilst cooling with ice
  2. stirringThe mixture was stirred for a further 30 minutes at 50° C.
  3. dissolutionthe constituents which had not dissolved
  4. filtrationwere then filtered off
  5. customthe filtrate was evaporated under reduced pressure
  6. dissolutionThe combined residues were dissolved in hot water
  7. customthe reaction product precipitated out
  8. filtrationThis was filtered off
  9. washwashed with water
  10. customdried

Quellen und Nachweise

ORD-Eintrag
ord-71f6c33c0e4c4ed0b12aa50256301303
Quelldatensatz
uspto-grants-1980_11
Patentnummer
US04233058

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