4-(3-(Trifluoromethyl)phenyl)-1-piperazineethanol → Ethyl 2-(8-trifluoromethyl-4-quinolinylamino)-5-fluorobenzoate

HRID 224594Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 224594
[F:1][C:2]([F:26])([F:25])[C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[CH:10][CH:9]=[C:8]2[NH:13][C:14]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:15]=1[C:16]([O:18][CH3:19])=[O:17].F[C:28](F)(F)C1C=C(N2CCN(CCO)CC2)C=CC=1>>[F:26][C:2]([F:1])([F:25])[C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[CH:10][CH:9]=[C:8]2[NH:13][C:14]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:15]=1[C:16]([O:18][CH2:19][CH3:28])=[O:17]

Komponenten

3

Edukt 2

HCID 2179944-(3-(Trifluoromethyl)phenyl)-1-piperazineethanolHCID 23331699Methyl 2-(8-trifluoromethyl-4-quinolinylamino)-5-fluoro-benzoate

Produkt 1

HCID 86737324Ethyl 2-(8-trifluoromethyl-4-quinolinylamino)-5-fluorobenzoate

Versuchsvorschrift

Using the procedure of Example 13, methyl 2-(8-trifluoromethyl-4-quinolinylamino)-5-fluoro-benzoate and 2-[-4-(3-trifluoromethylphenyl)-piperazin-1-yl]-ethanol were reacted to obtain 2-[4-3-trifluoromethylphenyl)-piperazin-1-yl]-ethyl 2-(8-trifluoromethyl-4-quinolinylamino)-5-fluorobenzoate. The said product was dissolved in absolute ethanol and an ethanolic solution of hydrogen chloride was added thereto followed by anhydrous ether. The mixture crystallized was vacuum filtered and the product was washed with anhydrous ether and was dried to form the desired hydrochloride salt melting at 230°-240° C.

Aufarbeitung

  1. customwere reacted

Quellen und Nachweise

ORD-Eintrag
ord-6cb0733c43ea4c23ba30073be53b3ff7
Quelldatensatz
uspto-grants-1980_11
Patentnummer
US04233305

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