Dota → 1,4,7,10-Tetraazacyclododecane

HRID 22460

Reaktionsgleichung

Reaktionsgleichung von HRID 22460
[CH2:1]1[N:12](CC(O)=O)[CH2:11][CH2:10][N:9](CC(O)=O)[CH2:8][CH2:7][N:6](CC(O)=O)[CH2:5][CH2:4][N:3](CC(O)=O)[CH2:2]1.[CH2:29]1[CH2:42][N:41](CC(O)=O)[CH2:40][CH2:39][N:38](CC(O)=O)[CH2:37][CH2:36][CH2:35][N:34](CC(O)=O)[CH2:33][CH2:32][N:31](CC(O)=O)[CH2:30]1>>[NH:3]1[CH2:4][CH2:5][NH:6][CH2:7][CH2:8][NH:9][CH2:10][CH2:11][NH:12][CH2:1][CH2:2]1.[NH:31]1[CH2:30][CH2:29][CH2:42][NH:41][CH2:40][CH2:39][NH:38][CH2:37][CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1

Komponenten

4

Edukt 2

HCID 121841DotaHCID 4502331,4,8,11-Tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid

Produkt 2

HCID 649631,4,7,10-TetraazacyclododecaneHCID 649641,4,8,11-Tetraazacyclotetradecane

Versuchsvorschrift

Accordingly, the invention provides a method for the synthesis of 1,4,7,10-tetraazacyclododecane N,N',N",N'"-tetraacetic acid (DOTA) and 1,4,8,11-tetraazacyclotetradecane N,N',N",N'"-tetraacetic acid (TETA) (Formula I). For this purpose 1,4,7,10-tetraazacyclododecane and 1,4,8,11-tetraazacyclotetradecane (Formula II) are provided and cyanomethylated using acid, formaldehyde, and cyanide compound yielding a tetranitrile (Formula III) which precipitates upon the addition of base.. The tetranitrile (Formula III) is hydrolyzed followed by acidification, evaporation to dryness, reconstitution and precipitation to give DOTA or TETA. ##STR5##

Aufarbeitung

  1. customAccordingly, the invention provides a method

Quellen und Nachweise

ORD-Eintrag
ord-4b124545ea2747e2b7cae4a0c6d18c48
Quelldatensatz
uspto-grants-1995_06
Patentnummer
US05428156

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