Benzenemethanethiol, alpha,alpha-diphenyl- → HCID 68599758, Verbindung

A solution of 2.73 g of 5-ethynyl-4-hydroxymethylthiazole in 65 ml of THF was cooled in ice under an argon atmosphere, and 6.5 g of triphenylmethane thiol and 440 mg of potassium-t-butoxide were added to the cooled solution. The mixture was stirred at room temperature for 2 hr. Brine was added to the reaction solution, and the mixture was extracted twice with ethyl acetate. The organic layers were combined, were washed with brine, were then dried over anhydrous magnesium sulfate, were filtered, and were concentrated under the reduced pressure. Ethyl acetate (10 ml) and 10 ml of hexane were added to the residue, and the resultant precipitate was collected by filtration to give 7.26 of the title compound.

1. extractionthe mixture was extracted twice with ethyl acetate
2. washwere washed with brine
3. dry with materialwere then dried over anhydrous magnesium sulfate
4. filtrationwere filtered
5. concentrationwere concentrated under the reduced pressure
6. additionEthyl acetate (10 ml) and 10 ml of hexane were added to the residue
7. filtrationthe resultant precipitate was collected by filtration

ORD-Eintrag

ord-b0068b566c8b4e40aa49123868046e11

Quelldatensatz

uspto-grants-2010_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07687490B2