Acetylthiourea → N-[4-Methyl-5-(3-nitro-phenyl)-thiazol-2-yl]-acetamide

HRID 2247341Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2247341
Br[CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-:14])=[O:13])[CH:7]=1)[C:3](=O)[CH3:4].[C:15]([NH:18][C:19]([NH2:21])=[S:20])(=[O:17])[CH3:16]>C(O)C>[CH3:4][C:3]1[N:21]=[C:19]([NH:18][C:15](=[O:17])[CH3:16])[S:20][C:2]=1[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-:14])=[O:13])[CH:7]=1

Komponenten

4

Edukt 2

HCID 2723593AcetylthioureaHCID 85861734HCID 85861734, Verbindung

Produkt 1

HCID 85861731N-[4-Methyl-5-(3-nitro-phenyl)-thiazol-2-yl]-acetamideAusbeute 52 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

A mixture of 1-bromo-1-(3-nitro-phenyl)-propan-2-one (Example 49a) (0.5 g, 1.94 mmol) and N-acetylthiourea (0.23 g, 1.94 mmol) in ethanol (10 ml) is stirred at 70° C. for 2 hours. After cooling the reaction to room temperature, the precipitated product is removed by filtration and dried under vacuum to give the titled compound (0.28 g).

Aufarbeitung

  1. temperatureAfter cooling
  2. customthe reaction to room temperature
  3. customthe precipitated product is removed by filtration
  4. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-801c59bd37d740668fe5a698b1bef334
Quelldatensatz
uspto-grants-2010_03
Patentnummer
US07687637B2

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