Phosphorus oxychloride → (2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetyl chloride

HRID 22480

Reaktionsgleichung

Reaktionsgleichung von HRID 22480
[NH2:1][C:2]1[S:6][N:5]=[C:4](/[C:7](=[N:11]/[O:12][CH3:13])/[C:8](O)=[O:9])[N:3]=1.P(Cl)(Cl)([Cl:16])=O>CN(C)C=O>[NH2:1][C:2]1[S:6][N:5]=[C:4](/[C:7](=[N:11]/[O:12][CH3:13])/[C:8]([Cl:16])=[O:9])[N:3]=1

Komponenten

4

Edukt 2

HCID 24813Phosphorus oxychlorideHCID 101304122-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetic acid

Produkt 1

HCID 10198354(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

In a manner similar to Example 1, a reaction was conducted using 2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(Z)-methoxyiminoacetic acid whose average particle size was 2.4 μ. Subsequent to dropwise addition of a chlorinating reagent which had been prepared from phosphorus oxychloride and N,N-dimethylformamide, they were reacted for 1 minute. The reaction product was post-treated, and its purity was analyzed by HPLC by the method described above.

Aufarbeitung

  1. additionSubsequent to dropwise addition of a chlorinating reagent which
  2. customwere reacted for 1 minute
  3. additionThe reaction product was post-treated

Quellen und Nachweise

ORD-Eintrag
ord-47b04d1b62284d4194a7e1e4dffe89e3
Quelldatensatz
uspto-grants-1995_06
Patentnummer
US05428173

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