Tetrahydrofuran → HCID 14579134, Verbindung

Reaktionsgleichung

[CH2:1]1[CH2:5][O:4][CH2:3][CH2:2]1.[O:6]1C=[CH:9][CH:8]=[C:7]1[NH:11][CH2:12][C:13]#[N:14].[CH3:15][N:16]1[CH:20]=C(C(Cl)=O)C=[N:17]1>C(N(CC)CC)C>[C:13]([CH:12]([C:3]1[O:4][CH:5]=[CH:1][CH:2]=1)[NH:11][C:7]([C:8]1[CH:9]=[N:17][N:16]([CH3:20])[CH:15]=1)=[O:6])#[N:14]

Komponenten

Versuchsvorschrift

To a THF solution containing the α-(2-furyl)aminoacetonitrile (2.15 g) and triethylamine (1.75 g) was added 1-methyl-1H-pyrazole-4-carboxylic acid chloride (2.55 g) under cooling with ice, and the whole was stirred for 1 hour as such and then for 16 hours at room temperature. The solid product formed was taken out by filtration, and the solvent was evaporated out, and then the thus-obtained oily product was purified by column chromatography and then washed with isopropyl ether, to give 2.55 g of the intended N-(cyano-2-furanylmethyl)-1-methyl-1H-pyrazole-4-carboxamide crystal.