3-Amino-4-chlorobenzoic acid → 3-[5-(1-t-Butoxyformamido)valeramido]-4-chlorobenzoic acid

HRID 2248509

Reaktionsgleichung

Reaktionsgleichung von HRID 2248509
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:16][C:17]1[CH:18]=[C:19]([CH:23]=[CH:24][C:25]=1[Cl:26])[C:20]([OH:22])=[O:21]>>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([NH:16][C:17]1[CH:18]=[C:19]([CH:23]=[CH:24][C:25]=1[Cl:26])[C:20]([OH:22])=[O:21])=[O:15])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Komponenten

3

Edukt 2

HCID 760923-Amino-4-chlorobenzoic acidHCID 5458485-(((Tert-butoxy)carbonyl)amino)pentanoic acid

Produkt 1

HCID 537516223-[5-(1-t-Butoxyformamido)valeramido]-4-chlorobenzoic acid

Versuchsvorschrift

For the preparation of the starting material, 5-[1-(t-butoxy)formamido]valeric acid and 3-amino-4-chlorobenzoic acid are coupled to give 3-[5-(1-t-butoxyformamido)valeramido]-4-chlorobenzoic acid, m.p. 203° C., and the latter is coupled with β-alanine t-butyl ester to give N-[3-[5-(1-t-butoxyformamido)valeramido]-4-chlorobenzoyl]-β-alanine t-butyl ester, MS: 498 (60, M+H).

Quellen und Nachweise

ORD-Eintrag
ord-64055d80423c4760b5e2dd3b8fc9038a
Quelldatensatz
uspto-grants-1991_08
Patentnummer
US05039805

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