1,1'-(Diazomethylene)bis(benzene) → HCID 178477369, Verbindung

HRID 224908

Reaktionsgleichung

Reaktionsgleichung von HRID 224908
[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]1[S:14][C:13]([CH2:15][C:16]([NH:18][C@@H:19]2[C:37](=[O:38])[N:21]3[C:22]([C:34]([OH:36])=[O:35])=[C:23]([CH:26]([S:28][C:29]4[NH:33][N:32]=[N:31][N:30]=4)[CH3:27])[CH2:24][S:25][C@H:20]23)=[O:17])=[CH:12][CH:11]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:39]1([C:45]([C:48]2[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=2)=[N+]=[N-])[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1>O1CCOCC1>[C:39]1([CH:45]([O:35][C:34]([C:22]2[N:21]3[C:37](=[O:38])[C@@H:19]([NH:18][C:16](=[O:17])[CH2:15][C:13]4[S:14][C:10]([CH2:9][NH:8][C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])=[CH:11][CH:12]=4)[C@H:20]3[S:25][CH2:24][C:23]=2[CH:26]([S:28][C:29]2[NH:30][N:31]=[N:32][N:33]=2)[CH3:27])=[O:36])[C:48]2[CH:49]=[CH:50][CH:51]=[CH:52][CH:53]=2)[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1

Komponenten

4

Edukt 2

HCID 612301,1'-(Diazomethylene)bis(benzene)HCID 178477380HCID 178477380, Verbindung

Produkt 1

HCID 178477369HCID 178477369, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

The product, containing 7β-[2-(5-tert.-butoxycarbonylaminomethyl-2-thienyl)-acetylamino]-3-(1-methyl-5-tetrazolylthiomethyl)-3-cephem-4-carboxylic acid, is dissolved in 30 ml of dioxane, 1.5 g of diphenyldiazomethane are added to the solution and the mixture is stirred for 12 hours at room temperature and then concentrated. After crystallisation from a mixture of methyl acetate and diethyl ether, the residue gives 7β-[2-(5-tert.-butoxycarbonylaminomethyl-2-thienyl)-acetylamino]-3-(1-methyl-5-tetrazolylthiomethyl)-3-cephem-4-carboxylic acid diphenylmethyl ester.

Aufarbeitung

  1. concentrationconcentrated
  2. customAfter crystallisation
  3. additionfrom a mixture of methyl acetate and diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-26a57672a0cd4dcfa2633c401bcadf91
Quelldatensatz
uspto-grants-1980_11
Patentnummer
US04234578

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