Potassium Bicarbonate → HCID 19825784, Verbindung

HRID 2249209Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2249209
C(O)(=O)C.C(O)(=O)C.[O:9]1[C:22]([CH3:24])([CH3:23])[CH:10]1[CH2:11][C:12]1[C:13]([OH:21])=[CH:14][C:15]([O:19][CH3:20])=[C:16]([CH:18]=1)[OH:17].C(=O)([O-])O.[K+]>CO>[OH:9][C:22]([CH:10]1[CH2:11][C:12]2[CH:18]=[C:16]([OH:17])[C:15]([O:19][CH3:20])=[CH:14][C:13]=2[O:21]1)([CH3:24])[CH3:23]

Komponenten

4

Edukt 2

HCID 516893Potassium BicarbonateHCID 86745023HCID 86745023, Verbindung

Produkt 1

HCID 19825784HCID 19825784, VerbindungAusbeute 80,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 5-(2,3-epoxy-3-methylbutyl)-2-methoxyhydroquinone diacetate (1.848 g) in methanol (36 ml) was added potassium hydrogencarbonate (1.50 g) in one portion. The mixture was stirred for 21 hours at ambient temperature and concentrated in vacuo. The residue was dissolved in a mixture of ethyl acetate (30 ml) and saturated sodium chloride solution (30 ml). The separated organic layer was washed with saturated sodium chloride solution, dried, and evaporated to dryness. The oily residue was crystallized from isopropyl ether to yield 2,3-dihydro-2-(1-hydroxy-1-methylethyl)-6-methoxy-5-benzofuranol (964 mg) as a white solid.

Aufarbeitung

  1. concentrationconcentrated in vacuo
  2. dissolutionThe residue was dissolved in a mixture of ethyl acetate (30 ml) and saturated sodium chloride solution (30 ml)
  3. washThe separated organic layer was washed with saturated sodium chloride solution
  4. customdried
  5. customevaporated to dryness
  6. customThe oily residue was crystallized from isopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-0e5d249d524f410ab85b84892ca7cddc
Quelldatensatz
uspto-grants-1991_08
Patentnummer
US05043354

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