Sodium Cyanide → alpha-Oxothiophen-2-acetonitrile

HRID 224942

Reaktionsgleichung

Reaktionsgleichung von HRID 224942
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](Cl)=[O:7].[C-:9]#[N:10].[Na+]>C(Cl)Cl>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([C:9]#[N:10])=[O:7]

Komponenten

4

Edukt 2

HCID 8929Sodium CyanideHCID 789282-Thiophenecarbonyl chloride

Produkt 1

HCID 80107alpha-Oxothiophen-2-acetonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A process for preparing thienylglyoxamide which comprises reacting thiophene carboxylic acid chloride with aqueous sodium cyanide in methylene chloride solvent and in the presence of a phase transfer catalyst to form thiophene carboxylic acid cyanide and reacting said thiophene carboxylic acid cyanide with concentrated hydrochloric acid at a temperature and for a time sufficient to form thienylglyoxamide.

Aufarbeitung

  1. customA process for preparing thienylglyoxamide which

Quellen und Nachweise

ORD-Eintrag
ord-6f4fb7a1d88f4025bff541cf774a000c
Quelldatensatz
uspto-grants-1980_11
Patentnummer
US04234737

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