4-(3-Hydroxypropylamino)-3-nitropyridine → 3-Amino-4-(3-hydroxypropylamino)pyridine

HRID 22495

Reaktionsgleichung

Reaktionsgleichung von HRID 22495
[OH:1][CH2:2][CH2:3][CH2:4][NH:5][C:6]1[CH:11]=[CH:10][N:9]=[CH:8][C:7]=1[N+:12]([O-])=O>C(O)C.[Ni]>[NH2:12][C:7]1[CH:8]=[N:9][CH:10]=[CH:11][C:6]=1[NH:5][CH2:4][CH2:3][CH2:2][OH:1]

Komponenten

4

Edukt 1

HCID 5923304-(3-Hydroxypropylamino)-3-nitropyridine

Produkt 1

HCID 190429283-Amino-4-(3-hydroxypropylamino)pyridine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

4-(3-Hydroxypropylamino)-3-nitropyridine (4.12 g, 20.9 mmol) was dissolved in ethanol (130 ml) and Raney nickel (411 mg, 7.0 mmol) added. The stirred mixture was hydrogenated for 3 days. The catalyst was removed by filtration under argon and the solvent removed under reduced pressure to give 3-amino-4-(3-hydroxypropylamino)pyridine as a brown oil which was used directly in the next step.

Aufarbeitung

  1. customThe catalyst was removed by filtration under argon
  2. customthe solvent removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-4c30fde3bc5e4f7d969c58ff09cd5573
Quelldatensatz
uspto-grants-1995_06
Patentnummer
US05428168

Verknüpfte Notizen

Wird geladen…