Methanol → 2-Methoxycarbonylaminohexanoic acid methyl ester

HRID 224953Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 224953
[CH3:1][O:2][C:3](=[O:10])[CH:4](Cl)[CH2:5][CH2:6][CH2:7][CH3:8].[O-:11][C:12]#[N:13].[K+].[CH3:15][OH:16]>CN(C=O)C>[CH3:1][O:2][C:3](=[O:10])[CH:4]([NH:13][C:12]([O:16][CH3:15])=[O:11])[CH2:5][CH2:6][CH2:7][CH3:8]

Komponenten

5

Edukt 3

HCID 887MethanolHCID 85786Methyl 2-chlorohexanoateHCID 11378442Potassium cyanate

Produkt 1

HCID 536557612-Methoxycarbonylaminohexanoic acid methyl esterAusbeute 67 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

11.52 grams of 2-chlorohexanoic acid methyl ester were heated with 8.52 grams of potassium cyanate and 7.85 grams of methanol in 70 ml of DMF. After a reaction time of 30 hours the reaction mixture was worked up as described in Example 1. There were obtained 9.53 grams (67%) of 2-methoxycarbonylaminohexanoic acid methyl ester with a purity of 99% (determined gas chromatographically).

Aufarbeitung

  1. customAfter a reaction time of 30 hours

Quellen und Nachweise

ORD-Eintrag
ord-504dd33590194b8ea0bde7260b19dc3c
Quelldatensatz
uspto-grants-1980_11
Patentnummer
US04234744

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