Cyclohexylamine → HCID 59639572, Verbindung

HRID 2250091Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2250091
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[CH:21]=[CH:20][C:19](=[O:22])[N:18]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[CH3:29])[C:10]=3[N:11]=[C:12](S(C)(=O)=O)[N:13]=2)=[C:4]([CH3:30])[CH:3]=1.[CH:31]1([NH2:37])[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1>>[CH:31]1([NH:37][C:12]2[N:13]=[C:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][C:4]=3[CH3:30])[C:9]3[CH:21]=[CH:20][C:19](=[O:22])[N:18]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[CH3:29])[C:10]=3[N:11]=2)[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1

Komponenten

3

Edukt 2

HCID 7965CyclohexylamineHCID 59639608HCID 59639608, Verbindung

Produkt 1

HCID 59639572HCID 59639572, VerbindungAusbeute 48,1 %

Versuchsvorschrift

Following the general procedure outlined in Example 126, the product of Example 121 (200 mg, 0.47 mmol), and cyclohexylamine (0.27 mL, 2.36 mmol) were reacted to give the crude material, which was purified as described in Example 198 to give the desired product 100 mg (48%). LC-MS: 443.4 (MH+, m/z), 2.79 (Rt, min).

Aufarbeitung

  1. customto give the crude material, which
  2. customwas purified

Quellen und Nachweise

ORD-Eintrag
ord-475b9ed1bd634f4cb859c4b7d59ea46c
Quelldatensatz
uspto-grants-2008_01
Patentnummer
US07314934B2

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