Hydrochloric Acid → HCID 11353031, Verbindung

HRID 2250431Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2250431
C[O:2][C:3]([C:5]1[CH:6]=[C:7]2[CH:13]=[C:12]([C:14](=[O:25])[NH:15][CH:16]3[CH2:21][CH2:20][N:19]([CH:22]([CH3:24])[CH3:23])[CH2:18][CH2:17]3)[N:11]([CH2:26][C:27]3[CH:31]=[C:30]([C:32]4[S:33][C:34]([Cl:37])=[CH:35][CH:36]=4)[O:29][N:28]=3)[C:8]2=[N:9][CH:10]=1)=[O:4].[OH-].[Na+].Cl>CO>[Cl:37][C:34]1[S:33][C:32]([C:30]2[O:29][N:28]=[C:27]([CH2:26][N:11]3[C:8]4=[N:9][CH:10]=[C:5]([C:3]([OH:4])=[O:2])[CH:6]=[C:7]4[CH:13]=[C:12]3[C:14](=[O:25])[NH:15][CH:16]3[CH2:17][CH2:18][N:19]([CH:22]([CH3:23])[CH3:24])[CH2:20][CH2:21]3)[CH:31]=2)=[CH:36][CH:35]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 11307256HCID 11307256, Verbindung

Produkt 1

HCID 11353031HCID 11353031, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

To a solution of 630 mg of 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-2-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester in 60 mL MeOH, 8.7 mL of a 1M aqueous NaOH solution were added. The reaction mixture was heated to 60° C. for 3 h. After cooling to RT 8.8 mL of a 1M aqueous HCl were added and the solvents were removed under reduced pressure. The residue was stirred with water/MeCN 2:1 and the precipitated product was collected by filtration.

Aufarbeitung

  1. additionwere added
  2. customthe solvents were removed under reduced pressure
  3. filtrationthe precipitated product was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-15c2208ae312437e8d9063e28921c1ea
Quelldatensatz
uspto-grants-2008_01
Patentnummer
US07317027B2

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