Ethyl 7-acetyl-7-(4-cyanobenzoyl)-8-oxononanoate → HCID 57444530, Verbindung

HRID 2250558Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2250558
[C:1]([C:4]([C:18](=[O:27])[C:19]1[CH:24]=[CH:23][C:22]([C:25]#[N:26])=[CH:21][CH:20]=1)(C(=O)C)[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])(=[O:3])[CH3:2]>FC(F)(F)C(O)=O>[C:25]([C:22]1[CH:21]=[CH:20][C:19]([C:18]([CH:4]([C:1](=[O:3])[CH3:2])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])=[O:27])=[CH:24][CH:23]=1)#[N:26]

Komponenten

3

Edukt 1

HCID 57444529Ethyl 7-acetyl-7-(4-cyanobenzoyl)-8-oxononanoate

Produkt 1

HCID 57444530HCID 57444530, VerbindungAusbeute 72,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Reaktionsbedingungen

Temperatur
20 °C

Versuchsvorschrift

Ethyl 7-acetyl-7-(4-cyanobenzoyl)-8-oxononanoate (3.5 g) was dissolved in trifluoroacetic acid (12.6 ml) and the mixture was stirred at 20° C. for 15 minutes. The mixture was partitioned between ethyl acetate and water. The organic layer was separated, washed with water, aqueous sodium bicarbonate and brine, dried over MgSO4 (magnesium sulfate), and evaporated to give ethyl 7-(4-cyanobenzoyl)-8-oxononanoate (2.25 g) as an oil.

Aufarbeitung

  1. customThe mixture was partitioned between ethyl acetate and water
  2. customThe organic layer was separated
  3. washwashed with water, aqueous sodium bicarbonate and brine
  4. dry with materialdried over MgSO4 (magnesium sulfate)
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-c2cc236948be4a52b489f0381d3e631c
Quelldatensatz
uspto-grants-2008_01
Patentnummer
US07317009B2

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