6-Iodoindoline → 5-Methyl-thiophene-2-carboxylic acid [7-(2,3-dihydro-1H-indol-6-yl)-4-methoxy-benzothiazol-2-yl]-amide

HRID 2250748Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2250748
I[C:2]1[C:10]2[S:9][C:8]([NH:11][C:12]([C:14]3[S:15][C:16]([CH3:19])=[CH:17][CH:18]=3)=[O:13])=[N:7][C:6]=2[C:5]([O:20][CH3:21])=[CH:4][CH:3]=1.I[C:23]1[CH:31]=[C:30]2[C:26]([CH2:27][CH2:28][NH:29]2)=[CH:25][CH:24]=1>>[NH:29]1[C:30]2[C:26](=[CH:25][CH:24]=[C:23]([C:2]3[C:10]4[S:9][C:8]([NH:11][C:12]([C:14]5[S:15][C:16]([CH3:19])=[CH:17][CH:18]=5)=[O:13])=[N:7][C:6]=4[C:5]([O:20][CH3:21])=[CH:4][CH:3]=3)[CH:31]=2)[CH2:27][CH2:28]1

Komponenten

3

Edukt 2

HCID 116156966-IodoindolineHCID 865849065-Methyl-thiophene-2-carboxylic acid (4-methoxy-7-iodo-benzothiazol-2-yl)-amide

Produkt 1

HCID 865849455-Methyl-thiophene-2-carboxylic acid [7-(2,3-dihydro-1H-indol-6-yl)-4-methoxy-benzothiazol-2-yl]-amide

Versuchsvorschrift

The title compound was prepared from 5-methyl-thiophene-2-carboxylic acid (7-iodo-4-methoxy-benzothiazol-2-yl)-amide (100 mg, 0.23 mmol) and 6-iodo-2,3-dihydro-1H-indole using the general procedure B in Example 54 as light brown crystals (26%), MS: m/e=422(M+H+).

Quellen und Nachweise

ORD-Eintrag
ord-90f8814d8ce44e37b7c9214c7c2d77c2
Quelldatensatz
uspto-grants-2008_01
Patentnummer
US07317007B2

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