HCID 11562815, Verbindung → HCID 11611759, Verbindung
Reaktionsgleichung
[OH:1][C@@H:2]([CH2:35][CH2:36][CH3:37])[C@@H:3]([NH:10][C:11](=[O:34])[CH2:12][C:13]([NH:15][C:16]1[CH:17]=[C:18]([NH:26]C(=O)OC(C)(C)C)[CH:19]=[C:20]([C:22]([F:25])([F:24])[F:23])[CH:21]=1)=[O:14])[CH2:4][NH:5][CH2:6][CH:7]([CH3:9])[CH3:8]>C(Cl)Cl>[NH2:26][C:18]1[CH:17]=[C:16]([NH:15][C:13](=[O:14])[CH2:12][C:11]([NH:10][C@H:3]([C@@H:2]([OH:1])[CH2:35][CH2:36][CH3:37])[CH2:4][NH:5][CH2:6][CH:7]([CH3:8])[CH3:9])=[O:34])[CH:21]=[C:20]([C:22]([F:25])([F:24])[F:23])[CH:19]=1Komponenten
3
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A sample of tert-butyl 3-(3-((2S,3S)-3-hydroxy-1-(isobutylamino)hexan-2-ylamino)-3-oxopropanamido)-5-(trifluoromethyl)phenylcarbamate (86 mg, title compound from Example 24) was dissolved in methylene chloride (2 mL). The resultant solution was cooled to 0° C. and charged with trifluoroacetic acid (1 mL). The mixture was allowed to warm to RT and stirred for 45 min before being concentrated in vacuo. The residue was purified by RP-HPLC to afford the TFA salt of the title compound as a white powder after lyopholization. MS found: (M+H)+=433.3.