Potassium Carbonate → 8-{2-[2-(2-Methyl-pyrrolidin-1-yl)-ethyl]-benzofuran-5-yl}-6,7-dihydro-5H-1,4,8a-triaza-s-indacene

HRID 2251126Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2251126
[N:1]1[N:12]2[C:4]([N:5]=[C:6]3[C:10](=[C:11]2[C:13]2[CH:14]=[CH:15][C:16]4[O:20][C:19]([CH2:21][CH2:22]OS(C)(=O)=O)=[CH:18][C:17]=4[CH:28]=2)[CH2:9][CH2:8][CH2:7]3)=[CH:3][CH:2]=1.[CH3:29][CH:30]1[CH2:34][CH2:33][CH2:32][NH:31]1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH3:29][CH:30]1[CH2:34][CH2:33][CH2:32][N:31]1[CH2:22][CH2:21][C:19]1[O:20][C:16]2[CH:15]=[CH:14][C:13]([C:11]3[N:12]4[C:4](=[CH:3][CH:2]=[N:1]4)[N:5]=[C:6]4[C:10]=3[CH2:9][CH2:8][CH2:7]4)=[CH:28][C:17]=2[CH:18]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 130032-MethylpyrrolidineHCID 58587719methanesulfonic acid 2-[5-(6,7-dihydro-5H-1,4,8a-triaza-s-indacen-8-yl)-benzo-furan-2-yl]-ethyl ester

Produkt 1

HCID 116252098-{2-[2-(2-Methyl-pyrrolidin-1-yl)-ethyl]-benzofuran-5-yl}-6,7-dihydro-5H-1,4,8a-triaza-s-indacene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

Methanesulfonic acid 2-[5-(6,7-dihydro-5H-1,4,8a-triaza-s-indacen-8-yl)-benzo-furan-2-yl]-ethyl ester (0.085 mmol) was dissolved in acetonitrile (2 ml) followed by addition of 2-methylpyrrolidine (0.85 mmol) and potassium carbonate (0.425 mmol) and heated to 70° C. for 24 hours. The reaction was cooled, filtered and concentrated. The residue was purified via preparative HPLC to give the title compound.

Aufarbeitung

  1. temperatureThe reaction was cooled
  2. filtrationfiltered
  3. concentrationconcentrated
  4. customThe residue was purified via preparative HPLC

Quellen und Nachweise

ORD-Eintrag
ord-b8341a033889438db7344175aaddd330
Quelldatensatz
uspto-grants-2008_01
Patentnummer
US07319103B2

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