Trifluoroacetic acid → 2-Methoxy-6-(piperazin-1-yl)pyrazine

Reaktionsgleichung

C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[N:18][CH:17]=[C:16]([O:20][CH3:21])[N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>>[CH3:21][O:20][C:16]1[N:15]=[C:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[CH:19]=[N:18][CH:17]=1

Komponenten

Edukt 2

HCID 6422Trifluoroacetic acid

HCID 690413416'-Methoxy-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-carboxylic acid tert-butyl ester

Produkt 1

HCID 133186982-Methoxy-6-(piperazin-1-yl)pyrazine

Versuchsvorschrift

Prepared in analogy to example 4.10 (c) from 6′-Methoxy-2,3,5,6-tetrahydro-[1,2′]bipyrazinyl-4-carboxylic acid tert-butyl ester and trifluoroacetic acid. MS (m/e): 195.1 (MH+, 80%)

Quellen und Nachweise

ORD-Eintrag: ord-ddeed2bd50a942b9afded2d572acd744
Quelldatensatz: uspto-grants-2008_01
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07319099B2

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