Triethylamine → 5-Chloro-2-(trifluoromethyl)pyrimidine

HRID 2251290

Reaktionsgleichung

Reaktionsgleichung von HRID 2251290
[F:1][C:2]([F:7])([F:6])[C:3]([NH2:5])=[NH:4].F[P-](F)(F)(F)(F)F.[Cl:15]/[C:16](=[CH:21]\N(C)C)/[CH:17]=[N+](C)C.C(N(CC)CC)C>C(#N)C>[Cl:15][C:16]1[CH:17]=[N:4][C:3]([C:2]([F:7])([F:6])[F:1])=[N:5][CH:21]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 2776882TrifluoroacetamidineHCID 105908072-Chloro-1,3-bis(dimethylamino)trimethinium hexafluorophosphate

Produkt 1

HCID 336979605-Chloro-2-(trifluoromethyl)pyrimidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

To a solution of 38 mmol trifluoroacetamidine in 70 ml acetonitrile was added 37.92 mmol ((Z)-2-Chloro-3-dimethylamino-allylidene)-dimethyl-ammonium hexafluoro phosphate (CAS: 291756-76-8) followed by 45.5 mmol triethylamine. The yellow solution was stirred at room temperature for 5 hours, then poured onto water and extracted 3 times with ether. The combined extracts were dried over sodium sulfate, filtered and distilled at 760 mm Hg to provide the title compound. MS (m/e): 182.2 (M+, 100%)

Aufarbeitung

  1. additionpoured onto water
  2. extractionextracted 3 times with ether
  3. dry with materialThe combined extracts were dried over sodium sulfate
  4. filtrationfiltered
  5. distillationdistilled at 760 mm Hg

Quellen und Nachweise

ORD-Eintrag
ord-babf65cbf0e34e788a9ad44df9f6edb9
Quelldatensatz
uspto-grants-2008_01
Patentnummer
US07319099B2

Verknüpfte Notizen

Wird geladen…