Chlorosuccinimide → 5-Chloro-2-hydroxy-3-methoxybenzoic acid

Beteiligte Stoffe

Reaktionsschritte

step a) 2-hydroxy-3-methoxy-benzoic acid (13) is chlorinated for example with N-chlorosuccinimide in acetic acid to yield 5-chloro-2-hydroxy-3-methoxy benzoic acid (14); step b) the methoxy group of compound (14) is reacted with hydrobromic acid in acetic acid to yield 5-chloro-2,3-dihydroxybenzoic acid (15);

Herkunft & Nachweise