Methyl iodide → Methyl 2-bromo-6-methylbenzoate

HRID 2251839Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2251839
[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[C:3]=1[C:4]([OH:6])=[O:5].[C:12]([O-])([O-])=O.[K+].[K+].CI>CC(C)=O>[CH3:12][O:5][C:4](=[O:6])[C:3]1[C:7]([CH3:11])=[CH:8][CH:9]=[CH:10][C:2]=1[Br:1]

Komponenten

5

Edukt 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 27355892-Bromo-6-methylbenzoic acid

Produkt 1

HCID 11564857Methyl 2-bromo-6-methylbenzoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

2-Bromo-6-methyl-benzoic acid (4.95 g) and K2CO3 (16.26 g) were suspended in acetone (150 mL). MeI (7.5 mL) was added and the mixture was heated at reflux for 3.5 h. The solid was removed by filtration and the filtrate was concentrated. The residue was taken into EtOAc and washed with saturated NH4Cl, H2O and saturated NaCl. The organic phase was dried over MgSO4, filtered, and concentrated to yield 2-bromo-6-methyl-benzoic acid methyl ester as an orange oil.

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 3.5 h
  3. customThe solid was removed by filtration
  4. concentrationthe filtrate was concentrated
  5. washwashed with saturated NH4Cl, H2O and saturated NaCl
  6. dry with materialThe organic phase was dried over MgSO4
  7. filtrationfiltered
  8. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-258638c855684139a2cae26e710ae1db
Quelldatensatz
uspto-grants-2008_01
Patentnummer
US07320992B2

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