Ether hydrochloride → (R)-2-Fluoro-5,11-dihydro-5-[1-(4-pyrrolidinophenethyl)pyrrolidin-2-yl-methyl]dibenzo[b,e][1,4]oxazepine dihydrochloride

HRID 2251890Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2251890
[ClH:1].C(OCC)C.[F:7][C:8]1[CH:41]=[CH:40][C:11]2[N:12]([CH2:21][C@H:22]3[CH2:26][CH2:25][CH2:24][N:23]3[CH2:27][CH2:28][C:29]3[CH:34]=[CH:33][C:32]([N:35]4[CH2:39][CH2:38][CH2:37][CH2:36]4)=[CH:31][CH:30]=3)[C:13]3[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=3[O:15][CH2:16][C:10]=2[CH:9]=1>ClCCl>[ClH:1].[ClH:1].[F:7][C:8]1[CH:41]=[CH:40][C:11]2[N:12]([CH2:21][C@H:22]3[CH2:26][CH2:25][CH2:24][N:23]3[CH2:27][CH2:28][C:29]3[CH:30]=[CH:31][C:32]([N:35]4[CH2:36][CH2:37][CH2:38][CH2:39]4)=[CH:33][CH:34]=3)[C:13]3[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=3[O:15][CH2:16][C:10]=2[CH:9]=1

Komponenten

4

Edukt 2

HCID 10953452Ether hydrochlorideHCID 59644017(R)-2-fluoro-5,11-dihydro-5-[1-(4-pyrrolidinophenethyl)pyrrolidin-2-ylmethyl]dibenzo[b,e][1,4]oxazepine

Produkt 1

HCID 69199662(R)-2-Fluoro-5,11-dihydro-5-[1-(4-pyrrolidinophenethyl)pyrrolidin-2-yl-methyl]dibenzo[b,e][1,4]oxazepine dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

20 ml of 2 M hydrogen chloride/diethyl ether was added to a solution of (R)-2-fluoro-5,11-dihydro-5-[1-(4-pyrrolidinophenethyl)pyrrolidin-2-ylmethyl]dibenzo[b,e][1,4]oxazepine (2.29 g) in dichloromethane (30 ml), and they were stirred together for 2 hours. The solvent was evaporated under reduced pressure. The obtained residue was solidified by stirring it in hexane. The solid thus precipitated was taken by the filtration to obtain the title compound in the form of a brown solid (2.17 g, 81%).

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure
  2. stirringby stirring it in hexane
  3. customThe solid thus precipitated
  4. filtrationwas taken by the filtration

Quellen und Nachweise

ORD-Eintrag
ord-2d74ee5d69dc4e049fc1c5f8d437f749
Quelldatensatz
uspto-grants-2008_01
Patentnummer
US07320973B2

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