Ether hydrochloride → (r)-5,11-Dihydro-5-[1-(3-pyrrolidinophenethyl)pyrrolidin-2-ylmethyl]-dibenzo[b,e][1,4]oxazepine dihydrochloride

HRID 2251901Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2251901
[ClH:1].C(OCC)C.[N:7]1([C:12]2[CH:13]=[C:14]([CH:38]=[CH:39][CH:40]=2)[CH2:15][CH2:16][N:17]2[CH2:21][CH2:20][CH2:19][C@@H:18]2[CH2:22][N:23]2[C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=3[CH2:27][O:26][C:25]3[CH:34]=[CH:35][CH:36]=[CH:37][C:24]2=3)[CH2:11][CH2:10][CH2:9][CH2:8]1>ClCCl>[ClH:1].[ClH:1].[N:7]1([C:12]2[CH:13]=[C:14]([CH:38]=[CH:39][CH:40]=2)[CH2:15][CH2:16][N:17]2[CH2:21][CH2:20][CH2:19][C@@H:18]2[CH2:22][N:23]2[C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=3[CH2:27][O:26][C:25]3[CH:34]=[CH:35][CH:36]=[CH:37][C:24]2=3)[CH2:11][CH2:10][CH2:9][CH2:8]1

Komponenten

4

Edukt 2

HCID 10953452Ether hydrochlorideHCID 12990604(r)-5,11-Dihydro-5-[1-(3-pyrrolidinophenethyl)pyrrolidin-2-ylmethyl]dibenzo[b,e][1,4]oxazepine

Produkt 1

HCID 69201019(r)-5,11-Dihydro-5-[1-(3-pyrrolidinophenethyl)pyrrolidin-2-ylmethyl]-dibenzo[b,e][1,4]oxazepine dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

2.0 ml of 2 M hydrogen chloride/diethyl ether was added to a solution of (R)-5,11-dihydro-5-[1-(3-pyrrolidinophenethyl)pyrrolidin-2-ylmethyl]dibenzo[b,e][1,4]oxazepine (208 mg) in dichloromethane (2 ml), and they were stirred together for 2 hours. The solvent was evaporated under reduced pressure. The obtained residue was solidified by stirring it in hexane. The solid thus precipitated was taken by the filtration to obtain the title compound in the form of a light brown solid (220 mg, 91%).

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure
  2. stirringby stirring it in hexane
  3. customThe solid thus precipitated
  4. filtrationwas taken by the filtration

Quellen und Nachweise

ORD-Eintrag
ord-3e3623e7f1c44c4aa5e093cb67b95be7
Quelldatensatz
uspto-grants-2008_01
Patentnummer
US07320973B2

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