Hydrochloric Acid → 7-(alpha,alpha,alpha-Trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

HRID 225245Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 225245
[Na+].[F:2][C:3]([F:23])([F:22])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:15]3[N:16]=[CH:17][C:18]([C:19]([O-:21])=[O:20])=[C:14]3[N:13]=[CH:12][CH:11]=2)[CH:5]=1.Cl>C(Cl)Cl>[F:22][C:3]([F:2])([F:23])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:15]3[N:16]=[CH:17][C:18]([C:19]([OH:21])=[O:20])=[C:14]3[N:13]=[CH:12][CH:11]=2)[CH:5]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 705907417-(alpha,alpha,alpha-Trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid sodium salt

Produkt 1

HCID 103353477-(alpha,alpha,alpha-Trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of 0.70 g. of 7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid sodium salt, 25 ml. of methylene chloride and 10 ml. of 1 N hydrochloric acid is stirred overnight. The solid which forms is collected by filtration. The filtrate is evaporated to produce more solid. The solids are combined and recrystallized from methylene chloride giving the desired product, m.p. 248°-250° C.

Aufarbeitung

  1. additionA mixture of 0.70 g
  2. filtrationThe solid which forms is collected by filtration
  3. customThe filtrate is evaporated
  4. customto produce more solid
  5. customrecrystallized from methylene chloride giving the desired product, m.p. 248°-250° C.

Quellen und Nachweise

ORD-Eintrag
ord-47fa7c9462a149e9883f1d2ac00e095a
Quelldatensatz
uspto-grants-1980_11
Patentnummer
US04236005

Notizen zur Reaktion

Wird geladen…