Sodium Hydroxide → Sodium 5-(1,1-dioxido-1,2-thiazinan-2-yl)-7-[({4-fluoro-2-[(isopropylamino)carbonyl]benzyl}amino)carbonyl]-1,6-naphthyridin-8-olate

HRID 2252814Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2252814
[O:1]=[S:2]1(=[O:36])[CH2:7][CH2:6][CH2:5][CH2:4][N:3]1[C:8]1[N:17]=[C:16]([C:18]([NH:20][CH2:21][C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][C:23]=2[C:29]([NH:31][CH:32]([CH3:34])[CH3:33])=[O:30])=[O:19])[C:15]([OH:35])=[C:14]2[C:9]=1[CH:10]=[CH:11][CH:12]=[N:13]2.[OH-].[Na+:38]>CC(C)=O>[O:36]=[S:2]1(=[O:1])[CH2:7][CH2:6][CH2:5][CH2:4][N:3]1[C:8]1[N:17]=[C:16]([C:18]([NH:20][CH2:21][C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][C:23]=2[C:29]([NH:31][CH:32]([CH3:34])[CH3:33])=[O:30])=[O:19])[C:15]([O-:35])=[C:14]2[C:9]=1[CH:10]=[CH:11][CH:12]=[N:13]2.[Na+:38]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 30134005-(1,1-dioxothiazinan-2-yl)-N-[[4-fluoro-2-(isopropylcarbamoyl)phenyl]methyl]-8-hydroxy-1,6-naphthyridine-7-carboxamide

Produkt 1

HCID 69178932Sodium 5-(1,1-dioxido-1,2-thiazinan-2-yl)-7-[({4-fluoro-2-[(isopropylamino)carbonyl]benzyl}amino)carbonyl]-1,6-naphthyridin-8-olate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

5-(1,1-Dioxido-1,2-thiazinan-2-yl)-N-{4-fluoro-2-[(isopropylamino)carbonyl]benzyl}-8-hydroxy-1,6-naphthyridine-7-carboxamide (203 mg, 0.39 mmol) was suspended in acetone (2 mL) and sodium hydroxide (0.39 mL, 0.39 mmol, 1N aqueous solution) was added. The flask was gently warmed to make the solution homogeneous and the solution was then filtered through a glass fiber filter to remove any dust. The solution was stirred at room temperature until solids crashed out of solution. The solids were collected by vacuum filtration to give the title compound as a yellow solid.

Aufarbeitung

  1. temperatureThe flask was gently warmed
  2. filtrationthe solution was then filtered through a glass fiber
  3. filtrationfilter
  4. customto remove any dust
  5. filtrationThe solids were collected by vacuum filtration

Quellen und Nachweise

ORD-Eintrag
ord-2bc9496928ab47eaac43eadf78235904
Quelldatensatz
uspto-grants-2008_01
Patentnummer
US07323460B2

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