2-(azidomethyl)-4-chloro-N-methylbenzamide → 2-(aminomethyl)-N-methylBenzamide
Reaktionsgleichung
[N:1]([CH2:4][C:5]1[CH:14]=[C:13](Cl)[CH:12]=[CH:11][C:6]=1[C:7]([NH:9][CH3:10])=[O:8])=[N+]=[N-]>C(O)C>[NH2:1][CH2:4][C:5]1[CH:14]=[CH:13][CH:12]=[CH:11][C:6]=1[C:7]([NH:9][CH3:10])=[O:8]Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
2-(Azidomethyl)-4-chloro-N-methylbenzamide (0.88 g, 3.94 mmol) was dissolved in ethanol (25 mL), degassed, treated with 10% Pd on carbon (80 mg), and put under one atmosphere of hydrogen. After one hour the reaction was filtered through Celite, and concentrated in vacuo to afford 2-(aminomethyl)-N-methylbenzamide as a white solid.
Aufarbeitung
- customdegassed
- additiontreated with 10% Pd on carbon (80 mg)
- filtrationAfter one hour the reaction was filtered through Celite
- concentrationconcentrated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-65161268a57943528c12f6cddeccd3e2
- Quelldatensatz
- uspto-grants-2008_01
- Patentnummer
- US07323460B2
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