Sodium Hydroxide → N,N-di-isopropyloxamic acid

HRID 2253711Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2253711
[CH:1]([N:4]([CH:11]([CH3:13])[CH3:12])[C:5](=[O:10])[C:6]([O:8]C)=[O:7])([CH3:3])[CH3:2].[OH-].[Na+]>CO>[CH:11]([N:4]([CH:1]([CH3:3])[CH3:2])[C:5](=[O:10])[C:6]([OH:8])=[O:7])([CH3:13])[CH3:12]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 11769261HCID 11769261, Verbindung

Produkt 1

HCID 10910050N,N-di-isopropyloxamic acidAusbeute 35,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

550 mg of methyl N,N-di-isopropyloxamate was dissolved in 20 ml of methanol. The resulting solution was stirred under ice-cooling, to which 15 ml of 1N aqueous solution of sodium hydroxide was added dropwise. After completion of the dropwise addition, the resultant mixture was stirred for 1 hour at room temperature. The solvent was distilled off from the resulting reaction solution under reduced pressure. The residue was added with 20 ml of 1N HCl. Insoluble white precipitates were collected by filtration, washed with chilled water and n-hexane, and then dried to obtain 180 mg of the title compound, N,N-di-isopropyloxamic acid as white solids.

Aufarbeitung

  1. additionwas added dropwise
  2. additionAfter completion of the dropwise addition
  3. distillationThe solvent was distilled off from the resulting reaction solution under reduced pressure
  4. additionThe residue was added with 20 ml of 1N HCl
  5. customInsoluble white precipitates
  6. filtrationwere collected by filtration
  7. washwashed with chilled water and n-hexane
  8. customdried

Quellen und Nachweise

ORD-Eintrag
ord-deffe7e1489a47869fbb0ea41214ed17
Quelldatensatz
uspto-grants-1993_08
Patentnummer
US05232947

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