Thionyl Chloride → HCID 19744543, Verbindung

HRID 2254408Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2254408
O[CH2:2][C:3]1[CH:4]=[C:5]([N:9]2[CH:13]=[CH:12][N:11]=[CH:10]2)[CH:6]=[CH:7][CH:8]=1.S(Cl)([Cl:16])=O>C(Cl)(Cl)Cl>[Cl:16][CH2:2][C:3]1[CH:4]=[C:5]([N:9]2[CH:13]=[CH:12][N:11]=[CH:10]2)[CH:6]=[CH:7][CH:8]=1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 197444983-(1H-Imidazol-1-yl)benzenemethanol

Produkt 1

HCID 19744543HCID 19744543, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

90 mg of 1-(3-hydroxymethylphenyl)imidazole was dissolved in 10 ml of chloroform, and 100 microliters of thionyl chloride was added. The mixture was stirred at room temperature for 3 hours. The solvent was evaporated under reduced pressure. The residue was dissolved in a mixture of ethyl ether and water. The organic layer was separated, washed successively with a 5% aqueous solution of sodium hydrogen carbonate and then with water, and dried over anhydrous magnesium sulfate. The desiccant was separated by filtration and then ethyl ether was evaporated to give 1-(3-chloromethylphenyl)imidazole as a pale yellow oily product.

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure
  2. dissolutionThe residue was dissolved in a mixture of ethyl ether and water
  3. customThe organic layer was separated
  4. washwashed successively with a 5% aqueous solution of sodium hydrogen carbonate
  5. dry with materialwith water, and dried over anhydrous magnesium sulfate
  6. customThe desiccant was separated by filtration
  7. customethyl ether was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-6ee7d1e307c64f6fa8030df752486d9c
Quelldatensatz
uspto-grants-1993_08
Patentnummer
US05234946

Notizen zur Reaktion

Wird geladen…