HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Phenol → Methyl 2-(2-chloro-4-hydroxymethyl-6-methoxyphenoxy)-2-phenylacetate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Phenol | HCID 996 | — |
| Edukt | 3-Chloro-4-hydroxy-5-methoxybenzaldehyde | HCID 29622 | — |
| Edukt | Methyl 2-(2-bromophenyl)acetate | HCID 8063364 | — |
| Edukt | Acetone potassium carbonate | HCID 86600397 | — |
| Produkt | Methyl 2-(2-chloro-4-hydroxymethyl-6-methoxyphenoxy)-2-phenylacetate | HCID 19385663 | 64% |
Reaktionsschritte
Using the K2CO3 /acetone conditions for phenol alkylation described in Step A of Example 30, 0.50 g (2.65 mmol) of 3-chloro-4-hydroxy-5-methoxybenzaldehyde was alkylated with 0.668 g (2.92 mmol) of methyl 2-bromophenylacetate to afford 0.570 g (64%) of the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05240938 |
| Quelldatensatz | uspto-grants-1993_08 |
| ORD ID | ord-9a1472b7b0a744e88212cf8e7f15cd46 |
| Quellennotiz | uspto-grants-1993_08 |