Sodium Hydroxide → Ethyl 2,7-diazabicyclo[3.3.0]octane-2-carboxylate

HRID 2255685Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2255685
[CH:1]12[CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6][CH:5]1[CH2:4][CH2:3][N:2]2[C:16]([O:18][CH2:19][CH3:20])=[O:17].[OH-].[Na+]>C(Cl)(Cl)Cl>[CH:1]12[CH2:8][NH:7][CH2:6][CH:5]1[CH2:4][CH2:3][N:2]2[C:16]([O:18][CH2:19][CH3:20])=[O:17]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 191009335-(1,1-Dimethylethyl) 1-ethyl hexahydropyrrolo[3,4-b]pyrrole-1,5-dicarboxylate

Produkt 1

HCID 15070028Ethyl 2,7-diazabicyclo[3.3.0]octane-2-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

15.2 g (53.3 mol) of 2-ethyl 7-tert.-butyl 2,7-diazabicyclo[3.3.0]octane-2,7-dicarboxylate in 100 ml of chloroform are heated under reflux for five hours with 10.5 g (55.3 mol) of para-toluenesulphoic acid. The mixture is washeds with 50 ml of 10% strength sodium hydroxide solution, the organic phase is dried over potassium carbonate and concentrated, and the residue is distilled.

Aufarbeitung

  1. dry with materialthe organic phase is dried over potassium carbonate
  2. concentrationconcentrated
  3. distillationthe residue is distilled

Quellen und Nachweise

ORD-Eintrag
ord-1d3c889c1bd3449bb7eadfc4c870dee8
Quelldatensatz
uspto-grants-1993_08
Patentnummer
US05241076

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