2-Methylbenzoyl chloride → N-[4-[(5,6,7,8-Tetrahydro-4H-thieno[3,2-b]azepin-4-yl)carbonyl]phenyl]-2-methylbenzamide

HRID 2255982Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2255982
[NH2:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([N:8]2[CH2:14][CH2:13][CH2:12][CH2:11][C:10]3[S:15][CH:16]=[CH:17][C:9]2=3)=[O:7])=[CH:4][CH:3]=1.[CH3:20][C:21]1[CH:29]=[CH:28][CH:27]=[CH:26][C:22]=1[C:23](Cl)=[O:24]>ClCCl>[S:15]1[C:10]2[CH2:11][CH2:12][CH2:13][CH2:14][N:8]([C:6]([C:5]3[CH:4]=[CH:3][C:2]([NH:1][C:23](=[O:24])[C:22]4[CH:26]=[CH:27][CH:28]=[CH:29][C:21]=4[CH3:20])=[CH:19][CH:18]=3)=[O:7])[C:9]=2[CH:17]=[CH:16]1

Komponenten

4

Edukt 2

HCID 702762-Methylbenzoyl chlorideHCID 214671424-(4-Aminobenzoyl)-5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine

Produkt 1

HCID 11269308N-[4-[(5,6,7,8-Tetrahydro-4H-thieno[3,2-b]azepin-4-yl)carbonyl]phenyl]-2-methylbenzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

As described for Example 1, 4-(4-aminobenzoyl)-5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine (0.001 ml) is reacted with 2-methylbenzoyl chloride in dichloromethane to give the product. Crystallization from ethyl acetate-hexane gives crystals, m.p. 181°-182° C.

Aufarbeitung

  1. customto give the product
  2. customCrystallization from ethyl acetate-hexane
  3. customgives crystals, m.p. 181°-182° C.

Quellen und Nachweise

ORD-Eintrag
ord-ef0861ead96b4708ba6d7a0f3bf43a80
Quelldatensatz
uspto-grants-1997_08
Patentnummer
US05654297

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