Chlorpromazine Hydrochloride → Chlorpromazine

HRID 2256197Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2256197
Cl.[Cl:2][C:3]1[CH:16]=[CH:15][C:14]2[S:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[N:6]([CH2:17][CH2:18][CH2:19][N:20]([CH3:22])[CH3:21])[C:5]=2[CH:4]=1.[OH-].[Na+]>>[Cl:2][C:3]1[CH:16]=[CH:15][C:14]2[S:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[N:6]([CH2:17][CH2:18][CH2:19][N:20]([CH3:21])[CH3:22])[C:5]=2[CH:4]=1

Komponenten

3

Edukt 2

HCID 6240Chlorpromazine HydrochlorideHCID 14798Sodium Hydroxide

Produkt 1

HCID 2726ChlorpromazineAusbeute 98,2 %

Versuchsvorschrift

3.56 g (10 mmol) of 2-chloro-10-(3-dimethylaminopropyl) phenothiazine hydrochloride are suspended in 15 ml of a 1N sodium hydroxide solution. The amine freed is extracted with diethyl ether. The organic phase is decanted and dried over sodium sulfate and then evaporated to dryness to yield 3.13 g of an oil corresponding to the expected product.

Aufarbeitung

  1. extractionThe amine freed is extracted with diethyl ether
  2. customThe organic phase is decanted
  3. dry with materialdried over sodium sulfate
  4. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-54649aac1e7b49639dc875d5bdd33045
Quelldatensatz
uspto-grants-1997_08
Patentnummer
US05654323

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