N-Methylaniline → HCID 70196436, Verbindung

3-Phenylglutaric anhydride (8.0 g) in CH2Cl2 (100 mL) at 0° C. was treated sequentially with N-methylaniline (5.63 g), triethylamine (5.32 g) and N,N-dimethylaminopyridine (1.0 g). The mixture was stirred at 0° C. for two hours then allowed to warm to room temperature and stirred for 12 hours. The reaction mixture was washed with 1N HCl (2×50 mL) and water (100 mL). The organic layers were dried over MgSO4, filtered and concentrated to afford the title compound (11.5 g).

1. temperatureto warm to room temperature
2. stirringstirred for 12 hours
3. washThe reaction mixture was washed with 1N HCl (2×50 mL) and water (100 mL)
4. dry with materialThe organic layers were dried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated

ORD-Eintrag

ord-e0dc129092434f698273c319315df8be

Quelldatensatz

uspto-grants-1997_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05654316