Triethylamine → HCID 19029324, Verbindung

3-(3,4-Dichlorophenyl)glutaric anhydride (3.1 g, Example 1, Step C) in CH2Cl2 (50 mL) at 0° C. was treated sequentially with 3,5-bis-(trifluoromethyl)benzylamine (3.4 g), triethylamine (1.83 mL) and N,N-dimethylaminopyridine (150 mg). The mixture was stirred at 0° C. for two hours then allowed to warm to room temperature and stirred for 12 hours. The reaction mixture was diluted with CH2Cl2 (200 mL) and washed with 1N HCl (1×100 mL) and water (1×100 mL). The organic layers were dried over MgSO4, filtered and concentrated to afford the title compound (6.1 g).

1. temperatureto warm to room temperature
2. stirringstirred for 12 hours
3. washwashed with 1N HCl (1×100 mL) and water (1×100 mL)
4. dry with materialThe organic layers were dried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated

ORD-Eintrag

ord-8cda20053ef342ac8ecff8ba13052a99

Quelldatensatz

uspto-grants-1997_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05654316