Methanol → HCID 19027583, Verbindung

HRID 2256811Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2256811
[C:1]1([C:7]2[N:11]=[C:10]([CH2:12][CH2:13][C:14](O)=[O:15])[O:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CO>O1CCCC1>[C:1]1([C:7]2[N:11]=[C:10]([CH2:12][CH2:13][CH2:14][OH:15])[O:9][N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

4

Edukt 2

HCID 887MethanolHCID 6659683-(3-phenyl-1,2,4-oxadiazol-5-yl)propanoic acid

Produkt 1

HCID 19027583HCID 19027583, VerbindungAusbeute 56,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

A solution of 2.5 ml of borane-methyl sulfide complex in 2M solution in tetrahydrofuran, 920 mg of 3-(3-phenyl-1,2,4-oxadiazol 5-yl)-propanoic acid (prepared by SRIRASTAVA et al., J. Heterocycl. Chem., Vol. 21, p. 1193 (1984) and 20 ml of tetrahydrofuran was stirred for one hour at ambient temperature. 10 ml of methanol were added over 5 minutes and evaporation to dryness under reduced pressure was carried out. The residue was chromatographed on silica (eluant: ethyl acetate - hexane (6-4)) to obtain 485 mg of the expected product.

Aufarbeitung

  1. customevaporation to dryness under reduced pressure
  2. customThe residue was chromatographed on silica (eluant: ethyl acetate - hexane (6-4))

Quellen und Nachweise

ORD-Eintrag
ord-d6a7c392a358417da35aeb7f62c06421
Quelldatensatz
uspto-grants-1997_08
Patentnummer
US05656607

Notizen zur Reaktion

Wird geladen…