Formamide → 5-Fluoroisoindoline-1,3-dione
Reaktionsgleichung
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=O)[O:8][C:6](=[O:7])[C:5]2=[CH:11][CH:12]=1.C([NH2:15])=O>>[F:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:11][CH:12]=1)[C:6](=[O:7])[NH:15][C:9]2=[O:8]Komponenten
3
Reaktionsbedingungen
- Temperatur
- 200 °C
Versuchsvorschrift
A mixture of 144 mmol 4-fluorophthalic anhydride and 1.16 mol formamide was heated at 200° C. for 2 h. The reaction mixture was poured onto ice-water and the resulting crystals collected by filtration and dried in vacuo to afford the title compound as a yellow solid (100% yield). MS (m/e): 164.4 ([M−H]−, 100%).
Aufarbeitung
- additionThe reaction mixture was poured onto ice-water
- filtrationthe resulting crystals collected by filtration
- customdried in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-4d1aa1d4c0e743ae80a7cbddc416b708
- Quelldatensatz
- uspto-grants-2009_07
- Patentnummer
- US07557114B2
Notizen zur Reaktion
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