3-Bromo-1-propanol → 1-Pyrrolidinepropanol

HRID 225758

Reaktionsgleichung

Reaktionsgleichung von HRID 225758
Br[CH2:2][CH2:3][CH2:4][OH:5].[NH:6]1[CH2:10][CH2:9][CH2:8][CH2:7]1>C1(C)C=CC=CC=1>[N:6]1([CH2:2][CH2:3][CH2:4][OH:5])[CH2:10][CH2:9][CH2:8][CH2:7]1

Komponenten

4

Edukt 2

HCID 123083-Bromo-1-propanolHCID 31268Pyrrolidine

Produkt 1

HCID 2093421-Pyrrolidinepropanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

3-Bromopropan-1-ol (27.3 mL, 302 mmol) was added to a solution of pyrrolidine (47.2 g, 655 mmol) in toluene (1000 mL) and the mixture was stirred at room temperature for 48 hours. The reaction mixture was then filtered and the filtrate was evaporated under reduced pressure. The residue was distilled and the title product was obtained as a colourless liquid at 100° C./7 mmHg, (23.1 g, 59%).

Aufarbeitung

  1. filtrationThe reaction mixture was then filtered
  2. customthe filtrate was evaporated under reduced pressure
  3. distillationThe residue was distilled

Quellen und Nachweise

ORD-Eintrag
ord-2ac62587795a42abb14e610714f0697f
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07557121B2

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