Ethyl Acetate → HCID 86594851, Verbindung

HRID 225774

Reaktionsgleichung

Reaktionsgleichung von HRID 225774
[C:1]([NH2:11])(=[O:10])[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Br[CH:13]([CH3:21])[C:14](=O)[CH2:15][C:16]([O:18][CH3:19])=[O:17].C(OC(=O)C)C>CN(C)C=O>[CH3:21][C:13]1[O:10][C:1]([CH:2]=[CH:3][C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=2)=[N:11][C:14]=1[CH2:15][C:16]([O:18][CH3:19])=[O:17]

Komponenten

5

Edukt 3

HCID 8857Ethyl AcetateHCID 121352-Propenamide, 3-phenyl-HCID 9815681Methyl 4-bromo-3-oxopentanoate

Produkt 1

HCID 86594851HCID 86594851, VerbindungAusbeute 11,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

Cinnamamide (0.5 g) and methyl 4-bromo-3-oxopentanoate (0.71 g) were dissolved in N,N-dimethylformamide (2.5 ml) and the mixture was stirred 100° C. for 15 h. Ethylacetate (50 ml) was added, and the mixture was washed with water (100 ml) and then with saturated brine (100 ml), and dried (Na2SO4). Ethyl acetate was evaporated under reduced pressure and the obtained residue was purified by column chromatography to give the title compound (0.1 g).

Aufarbeitung

  1. washthe mixture was washed with water (100 ml)
  2. dry with materialwith saturated brine (100 ml), and dried (Na2SO4)
  3. customEthyl acetate was evaporated under reduced pressure
  4. customthe obtained residue was purified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-c173fd40267040489bc68ac8304425c8
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07557123B2

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