2,4-Dimethoxyphenyl isocyanate → Ethyl 2-(4-{2-[3-(2,4-dimethoxyphenyl)-1-heptylureido]ethyl}phenoxy)-2-methylpropionate

HRID 2258022Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2258022
[CH2:1]([NH:8][CH2:9][CH2:10][C:11]1[CH:25]=[CH:24][C:14]([O:15][C:16]([CH3:23])([CH3:22])[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:13][CH:12]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[CH3:26][O:27][C:28]1[CH:33]=[C:32]([O:34][CH3:35])[CH:31]=[CH:30][C:29]=1[N:36]=[C:37]=[O:38]>C(Cl)Cl>[CH3:26][O:27][C:28]1[CH:33]=[C:32]([O:34][CH3:35])[CH:31]=[CH:30][C:29]=1[NH:36][C:37](=[O:38])[N:8]([CH2:9][CH2:10][C:11]1[CH:12]=[CH:13][C:14]([O:15][C:16]([CH3:23])([CH3:22])[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:24][CH:25]=1)[CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

Komponenten

4

Edukt 2

HCID 6016372,4-Dimethoxyphenyl isocyanateHCID 23192930Ethyl 2-[4-(heptylaminoethyl)phenoxy]-2-methylpropionate

Produkt 1

HCID 22924175Ethyl 2-(4-{2-[3-(2,4-dimethoxyphenyl)-1-heptylureido]ethyl}phenoxy)-2-methylpropionate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

The product from step (d) (2.1 g) and 2,4-dimethoxyphenylisocyanate (1.1 g, Aldrich) were dissolved in CH2Cl2 (50 ml). The resulting solution was stirred at room temperature for 17 hours and then evaporated in vacuo. The residue was flash chromatographed through a silica column using hexanes/CH2C1 /EtOAc (50:25:25) as eluant to give the desired product as a very light brown oil (2.0 g).

Aufarbeitung

  1. customevaporated in vacuo
  2. customchromatographed through a silica column

Quellen und Nachweise

ORD-Eintrag
ord-c033c022daa94816a823a761b469f875
Quelldatensatz
uspto-grants-1997_08
Patentnummer
US05658944

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