Ibuprofen, (+-)- → Methyl 2-methylprop-2-enoate;2-methylprop-2-enoic acid

HRID 2258386

Reaktionsgleichung

Reaktionsgleichung von HRID 2258386
[C:1](O)(=O)C=C.[OH:6][C:7]([CH:9]([C:11]1C=CC(CC(C)C)=CC=1)[CH3:10])=[O:8]>>[C:7]([OH:8])(=[O:6])[C:9]([CH3:11])=[CH2:10].[CH3:1][O:6][C:7](=[O:8])[C:9]([CH3:11])=[CH2:10]

Komponenten

3

Versuchsvorschrift

Acrylic acid, ibuprofen and poly(acrylic acid) (MW 2,000) and (MW 5,000) were purchased from Aldrich. Poly(methacrylic acid-methylmethacrylate) (Eudragit L) was provided by Rhom Pharma (Germany). Thionyl chloride, oxalyl chloride, and acetic anhydride were freshly distilled under nitrogen prior to use. All solvents were analytical grade.

Quellen und Nachweise

ORD-Eintrag
ord-57aeddba888d4109b2b164a6f17e181b
Quelldatensatz
uspto-grants-1997_08
Patentnummer
US05660851

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