1,4,7,10-Tetraazacyclododecane → N-[3-(2-carboxybutyl)-2,4,6-triiodophenyl]-1,4,7,10-tetraazacyclododecane-1-acetamide

HRID 2258395

Reaktionsgleichung

Reaktionsgleichung von HRID 2258395
[NH:1]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8][NH:7][CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl[CH2:14][C:15]([NH:17][C:18]1[C:19]([I:33])=[C:20]([CH2:26][CH:27]([CH2:31][CH3:32])[C:28]([OH:30])=[O:29])[C:21]([I:25])=[CH:22][C:23]=1[I:24])=[O:16]>CC#N>[C:28]([CH:27]([CH2:31][CH3:32])[CH2:26][C:20]1[C:19]([I:33])=[C:18]([NH:17][C:15](=[O:16])[CH2:14][N:1]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8][NH:7][CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)[C:23]([I:24])=[CH:22][C:21]=1[I:25])([OH:30])=[O:29]

Komponenten

4

Edukt 2

HCID 649631,4,7,10-TetraazacyclododecaneHCID 229213893-[(2-Chloroacetyl)amino]-alpha-ethyl-2,4,6-triiodobenzenepropanoic acid

Produkt 1

HCID 22921399N-[3-(2-carboxybutyl)-2,4,6-triiodophenyl]-1,4,7,10-tetraazacyclododecane-1-acetamideAusbeute 75 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel2×

Versuchsvorschrift

According to the procedure described in Example 3, 105.8 g of 1,4,7,10-tetraazacyclododecane (0.62 mol) in 600 ml of CH3CN are added to a suspension of 40 g of 3-[(2-chloro-1-oxoethyl)amino]-α-ethyl-2,4,6-triiodobenzenepropanoic acid (prepared as described in Example 1) (0.62 mol) in 500 ml of CH3CN. 35.8 g of N-[3-(2-carboxybutyl)-2,4,6-triiodophenyl]-1,4,7,10-tetraazacyclododecane-1-acetamide (0.046 mol) are obtained.

Quellen und Nachweise

ORD-Eintrag
ord-6bf0101ca62045d2ab6efd03097a4757
Quelldatensatz
uspto-grants-1997_08
Patentnummer
US05660814

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