Bromoacetic Acid → 10-[2-[[3-(2-Carboxybutyl)-2,4,6-triiodophenyl]amino]-2-oxoethyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Bromoacetic Acid	HCID 6227	—
Edukt	N-[3-(2-carboxybutyl)-2,4,6-triiodophenyl]-1,4,7,10-tetraazacyclododecane-1-acetamide	HCID 22921399	—
Edukt	N-(3-carboxy-2,4,6-triiodophenyl)-1,4,7,10-tetraazacyclododecane-1-acetamide	HCID 22921403	—
Lösungsmittel	Water	HCID 962	—
Produkt	10-[2-[[3-(2-Carboxybutyl)-2,4,6-triiodophenyl]amino]-2-oxoethyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid	HCID 10677949	13,4%

Reaktionsschritte

According to the procedure described in Example 3, 17.74 g of bromoacetic acid (0.127 mol) in 20 ml of H2O are reacted with 25 g of compound (B) N-[3-(2-carboxybutyl)-2,4,6-triiodophenyl]-1,4,7,10-tetraazacyclododecane-1-acetamide (0.032 mol) in 20 ml of H2O. 4.1 g of 10-[2-[[3-(2-carboxybutyl)-2,4,6-triiodophenyl]amino]-2-oxoethyl ] -1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (0.0043 mol) are obtained.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US05660814
Quelldatensatz	uspto-grants-1997_08
ORD ID	ord-7908b8e73bc143ccb30229fadcbb398a
Quellennotiz	uspto-grants-1997_08