Phenol → Methyl 3-phenoxy-3-phenyl-2-hydroxybutyrate

HRID 2258457Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2258457
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:8]1([C:14]2([CH3:21])[O:20][CH:15]2[C:16]([O:18][CH3:19])=[O:17])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>>[O:7]([C:14]([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)([CH3:21])[CH:15]([OH:20])[C:16]([O:18][CH3:19])=[O:17])[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

3

Edukt 2

HCID 996PhenolHCID 228011Methyl 3-methyl-3-phenyloxirane-2-carboxylate

Produkt 1

HCID 15766824Methyl 3-phenoxy-3-phenyl-2-hydroxybutyrate

Versuchsvorschrift

28.2 g (0.3 mol) of phenol and 19.2 g (0.1 mol) of methyl 3-phenyl-2,3-epoxybutyrate are heated together for 6 hours at 100° C. After the excess phenol has been distilled off under greatly reduced pressure and the residue has been purified by chromatography over silica gel using a hexane/ethyl acetate mixture, 17.9 g of a slightly yellow oil are obtained.

Aufarbeitung

  1. distillationAfter the excess phenol has been distilled off under greatly reduced pressure
  2. customthe residue has been purified by chromatography over silica gel using a hexane/ethyl acetate mixture, 17.9 g of a slightly yellow oil
  3. customare obtained

Quellen und Nachweise

ORD-Eintrag
ord-d170f804c292465eab05bfc8ecc73c93
Quelldatensatz
uspto-grants-1997_08
Patentnummer
US05661106

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