Hydrochloric Acid → 4-(2-Chlorophenyl)-4-cyanopiperidine hydrochloride

HRID 2258491Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2258491
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1([C:22]#[N:23])[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]1>CCOC(C)=O>[ClH:2].[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1([C:22]#[N:23])[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 21712251Tert-butyl 4-(2-chlorophenyl)-4-cyanopiperidine-1-carboxylate

Produkt 1

HCID 223792744-(2-Chlorophenyl)-4-cyanopiperidine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A solution of EtOAc saturated with HCl (200 ml) was added to 4-(2-chlorophenyl)-4-cyano-N-(1,1-dimethylethoxycarbonyl)piperidine, (880 mg, 2.74 mmol). The resulting mixture was allowed to react for 1 hour at room temperature. The EtOAc was removed in vacuo affording 4-(2-Chlorophenyl)-4-cyanopiperidine hydrochloride as a white solid.

Aufarbeitung

  1. customto react for 1 hour at room temperature
  2. customThe EtOAc was removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-d99a9ddfd2d34ac59a53ac78cab988f3
Quelldatensatz
uspto-grants-1997_08
Patentnummer
US05661163

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