Hydrochloric Acid → 2-(4-(3,5-Dichlorophenylureido)phenoxy)-2-methylpropionic acid

HRID 2259260

Reaktionsgleichung

Reaktionsgleichung von HRID 2259260
[NH2:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][C:7]([CH3:12])([CH3:11])[C:8]([OH:10])=[O:9])=[CH:4][CH:3]=1.[Cl:15][C:16]1[CH:17]=[C:18]([N:23]=[C:24]=[O:25])[CH:19]=[C:20]([Cl:22])[CH:21]=1.O.Cl>N1C=CC=CC=1>[Cl:15][C:16]1[CH:17]=[C:18]([NH:23][C:24](=[O:25])[NH:1][C:2]2[CH:3]=[CH:4][C:5]([O:6][C:7]([CH3:12])([CH3:11])[C:8]([OH:10])=[O:9])=[CH:13][CH:14]=2)[CH:19]=[C:20]([Cl:22])[CH:21]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 944603,5-Dichlorophenyl isocyanateHCID 27749582-(4-Aminophenoxy)-2-methylpropanoic acid

Produkt 1

HCID 1953472-(4-(3,5-Dichlorophenylureido)phenoxy)-2-methylpropionic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

To a stirring solution of 4.95 g (0.025 mole) of 2-(4-aminophenoxy)-2-methylpropionic acid in 50 ml dry pyridine, 4.95 g (0.025 mole) of 3,5-dichlorophenyl isocyanate were added. After 1 hour stirring at room temperature, 150 ml water was added and the mixture was acidified with concentrated HCl. The precipitate was filtered, washed several times with cold water and dried. Recrystallization from aqueous acetone gave small plates 1.81 g (94%) MP 182°-184°.

Aufarbeitung

  1. filtrationThe precipitate was filtered
  2. washwashed several times with cold water
  3. customdried
  4. customRecrystallization from aqueous acetone
  5. customgave small plates 1.81 g (94%) MP 182°-184°

Quellen und Nachweise

ORD-Eintrag
ord-2609906c21db4039b75320cff996be04
Quelldatensatz
uspto-grants-1995_12
Patentnummer
US05472981

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